Off-the-shelf EBV-specific T cell immunotherapy for rituximab-refractory EBV-associated lymphoma following transplantation

BACKGROUND: Adoptive transfer of donor-derived EBV-specific cytotoxic T-lymphocytes (EBV-CTLs) can eradicate EBV-associated lymphomas (EBV-PTLD) after transplantation of hematopoietic cell (HCT) or solid organ (SOT) but is unavailable for most patients. METHODS: We developed a third-party, allogenei...

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Pubblicato in:J Clin Invest
Autori principali: Prockop, Susan, Doubrovina, Ekaterina, Suser, Stephanie, Heller, Glenn, Barker, Juliet, Dahi, Parastoo, Perales, Miguel A., Papadopoulos, Esperanza, Sauter, Craig, Castro-Malaspina, Hugo, Boulad, Farid, Curran, Kevin J., Giralt, Sergio, Gyurkocza, Boglarka, Hsu, Katharine C., Jakubowski, Ann, Hanash, Alan M., Kernan, Nancy A., Kobos, Rachel, Koehne, Guenther, Landau, Heather, Ponce, Doris, Spitzer, Barbara, Young, James W., Behr, Gerald, Dunphy, Mark, Haque, Sofia, Teruya-Feldstein, Julie, Arcila, Maria, Moung, Christine, Hsu, Susan, Hasan, Aisha, O’Reilly, Richard J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2020
Soggetti:
Clinical Medicine
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6994129/
https://ncbi.nlm.nih.gov/pubmed/31689242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI121127
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