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At last — linking ORMDL3 polymorphisms, decreased sphingolipid synthesis, and asthma susceptibility

Asthma is a common chronic respiratory disease that has a heritable component. Polymorphisms in the endoplasmic reticular protein orosomucoid-like protein 3 (ORMDL3), which regulates sphingolipid homeostasis, have been strongly linked with childhood-onset asthma. Despite extensive investigation, a l...

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Bibliografische gegevens
Gepubliceerd in:J Clin Invest
Hoofdauteur: Wills-Karp, Marsha
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2020
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6994107/
https://ncbi.nlm.nih.gov/pubmed/31929192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI134333
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