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Efficient in vivo synthesis of lasso peptide pseudomycoidin proceeds in the absence of both the leader and the leader peptidase

Bacterial lasso peptides are made from linear ribosomally synthesized precursors by specific cleavage at the leader–core junction site of the precursor by a dedicated protease recognizing the leader, followed by cyclisation of the newly formed N-terminus of the core part with a side chain of the int...

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Bibliographic Details
Published in:Chem Sci
Main Authors: Zyubko, Tatyana, Serebryakova, Marina, Andreeva, Julia, Metelev, Mikhail, Lippens, Guy, Dubiley, Svetlana, Severinov, Konstantin
Format: Artigo
Language:Inglês
Published: Royal Society of Chemistry 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6993621/
https://ncbi.nlm.nih.gov/pubmed/32055339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc02370d
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