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Is there a causal link between PTEN deficient tumors and immunosuppressive tumor microenvironment?
The PTEN tumor suppressor is the second most commonly inactivated gene across cancer types. While it’s role in PI3K/AKT and DNA damage pathways are clear, increasing evidences suggest that PTEN may also promote anti-tumor immunity. PTEN-deficient tumors are characterized by (i) reduced levels of cyt...
Enregistré dans:
| Publié dans: | J Transl Med |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BioMed Central
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6993356/ https://ncbi.nlm.nih.gov/pubmed/32000794 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-020-02219-w |
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