Structural insights into the process of GPCR-G protein complex formation

The crystal structure of the β2 adrenergic receptor (β2AR) bound to the G protein Gs captured the complex in a nucleotide-free state (β2AR-Gs(empty)). Unfortunately, the β2AR-Gs(empty) complex does not provide a clear explanation for G protein coupling specificity. Evidence from several sources sugg...

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Pubblicato in:Cell
Autori principali: Liu, Xiangyu, Xu, Xinyu, Hilger, Daniel, Aschauer, Philipp, Tiemann, Johanna K.S., Du, Yang, Liu, Hongtao, Hirata, Kunio, Sun, Xiaoou, Guixà-González, Ramon, Mathiesen, Jesper M., Hildebrand, Peter W., Kobilka, Brian K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6991123/
https://ncbi.nlm.nih.gov/pubmed/31080070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.04.021
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