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A Stochastic Multiscale Model of Cardiac Thin Filament Activation Using Brownian-Langevin Dynamics
We use Brownian-Langevin dynamics principles to derive a coarse-graining multiscale myofilament model that can describe the thin-filament activation process during contraction. The model links atomistic molecular simulations of protein-protein interactions in the thin-filament regulatory unit to sar...
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| Pubblicato in: | Biophys J |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Biophysical Society
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6990154/ https://ncbi.nlm.nih.gov/pubmed/31547973 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2019.08.003 |
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