Depletion of MLKL inhibits invasion of radioresistant nasopharyngeal carcinoma cells by suppressing epithelial-mesenchymal transition

BACKGROUND: To examine whether MLKL participated in the invasion of radiosensitive nasopharyngeal carcinoma (NPC) cell (CNE-2) and radioresistant NPC cell (CR) through regulating epithelial-mesenchymal transition (EMT). METHODS: siRNA and CRISPR/Cas9 technique were used to decrease MLKL expression i...

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Detalhes bibliográficos
Publicado no:Ann Transl Med
Main Authors: Dong, Yuanli, Sun, Yun, Huang, Yangle, Fang, Xumeng, Sun, Pian, Dwarakanath, Bilikere, Kong, Lin, Lu, Jiade Jay
Formato: Artigo
Idioma:Inglês
Publicado em: AME Publishing Company 2019
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6990020/
https://ncbi.nlm.nih.gov/pubmed/32042757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/atm.2019.11.104
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