Fenretinide treatment accelerates atherosclerosis development in apoE‐deficient mice in spite of beneficial metabolic effects

BACKGROUND AND PURPOSE: Fenretinide, a synthetic retinoid derivative first investigated for cancer prevention and treatment, has been shown to ameliorate glucose tolerance, improve plasma lipid profile and reduce body fat mass. These effects, together with its ability to inhibit ceramide synthesis,...

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Vydáno v:Br J Pharmacol
Hlavní autoři: Busnelli, Marco, Manzini, Stefano, Bonacina, Fabrizia, Soldati, Sabina, Barbieri, Silvia Stella, Amadio, Patrizia, Sandrini, Leonardo, Arnaboldi, Francesca, Donetti, Elena, Laaksonen, Reijo, Paltrinieri, Saverio, Scanziani, Eugenio, Chiesa, Giulia
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6989955/
https://ncbi.nlm.nih.gov/pubmed/31621898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14869
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