Liver-specific deletion of the Plpp3 gene alters plasma lipid composition and worsens atherosclerosis in apoE(−/−) mice

The PLPP3 gene encodes for a ubiquitous enzyme that dephosphorylates several lipid substrates. Genome-wide association studies identified PLPP3 as a gene that plays a role in coronary artery disease susceptibility. The aim of the study was to investigate the effect of Plpp3 deletion on atheroscleros...

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Udgivet i:Sci Rep
Main Authors: Busnelli, Marco, Manzini, Stefano, Hilvo, Mika, Parolini, Cinzia, Ganzetti, Giulia S., Dellera, Federica, Ekroos, Kim, Jänis, Minna, Escalante-Alcalde, Diana, Sirtori, Cesare R., Laaksonen, Reijo, Chiesa, Giulia
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5349609/
https://ncbi.nlm.nih.gov/pubmed/28291223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44503
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