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Vaccination with CD47 deficient tumor cells elicits an antitumor immune response in mice
Cancer cells are poorly immunogenic and have a wide range of mutations, which makes them unsuitable for use in vaccination treatment. Here, we show that elimination of CD47, a ligand for the myeloid cell inhibitory receptor SIRPα, from tumor cells by genetic deletion or antibody blocking, significan...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6989506/ https://ncbi.nlm.nih.gov/pubmed/31996683 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14102-4 |
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