NRARP displays either pro- or anti-tumoral roles in T-cell acute lymphoblastic leukemia depending on Notch and Wnt signaling

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy with a dismal prognosis in patients with resistant or relapsed disease. Although NOTCH is a known driver in T-ALL, its clinical inhibition has significant limitations. Our previous studies suggested that NRARP, a n...

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Publicat a:Oncogene
Autors principals: Pinto, Inês, Duque, Mafalda, Gonçalves, Joana, Akkapeddi, Padma, Oliveira, Mariana L., Cabrita, Rita, Yunes, J. Andrés, Durum, Scott K., Barata, João T., Fragoso, Rita
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6989401/
https://ncbi.nlm.nih.gov/pubmed/31586130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-1042-9
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