Dysregulated actin dynamics in activated PI3Kδ syndrome

Activated PI3Kδ syndrome (APDS) Type I results from gain-of-function mutations in PIK3CD, which encodes the p110δ subunit of PI3Kδ. Abnormal actin dynamics have been hypothesized to contribute to the lymphopenia associated with this disease but have not been studied in patients with APDS. We report...

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Detalhes bibliográficos
Publicado no:Clin Immunol
Main Authors: Wallace, Jacqueline G., Zambrano-Rodas, Pedro, Córdova-Calderón, Wilmer, Estrada-Turriate, Santiago, Mendoza-Quispe, Daniel, Ontiveros, Yesenia Limache, Geha, Raif S., Chou, Janet, Platt, Craig D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6989370/
https://ncbi.nlm.nih.gov/pubmed/31760094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2019.108311
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