Dysregulated actin dynamics in activated PI3Kδ syndrome

Activated PI3Kδ syndrome (APDS) Type I results from gain-of-function mutations in PIK3CD, which encodes the p110δ subunit of PI3Kδ. Abnormal actin dynamics have been hypothesized to contribute to the lymphopenia associated with this disease but have not been studied in patients with APDS. We report...

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Vydáno v:Clin Immunol
Hlavní autoři: Wallace, Jacqueline G., Zambrano-Rodas, Pedro, Córdova-Calderón, Wilmer, Estrada-Turriate, Santiago, Mendoza-Quispe, Daniel, Ontiveros, Yesenia Limache, Geha, Raif S., Chou, Janet, Platt, Craig D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6989370/
https://ncbi.nlm.nih.gov/pubmed/31760094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2019.108311
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