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Lipid droplets can promote drug accumulation and activation
Genetic screens in cultured human cells represent a powerful unbiased strategy to identify cellular pathways that determine drug efficacy, providing critical information for clinical development. We used insertional mutagenesis-based screens in haploid cells to identify genes required for the sensit...
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| Pubblicato in: | Nat Chem Biol |
|---|---|
| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6989039/ https://ncbi.nlm.nih.gov/pubmed/31932720 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-019-0447-7 |
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