Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome

Nonsteroidal anti-inflammatory drugs interfere with the metabolism of arachidonic acid to proinflammatory prostaglandins and leukotrienes by targeting cyclooxygenases (COXs), 5-lipoxygenase (LOX), or the 5-LOX–activating protein (FLAP). These and related enzymes act in conjunction with marked crosst...

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Veröffentlicht in:FASEB J
Hauptverfasser: Werner, Markus, Jordan, Paul M., Romp, Erik, Czapka, Anna, Rao, Zhigang, Kretzer, Christian, Koeberle, Andreas, Garscha, Ulrike, Pace, Simona, Claesson, Hans-Erik, Serhan, Charles N., Werz, Oliver, Gerstmeier, Jana
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2019
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6988863/
https://ncbi.nlm.nih.gov/pubmed/30735438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201802509R
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