BCL-W is dispensable for the sustained survival of select Burkitt lymphoma and diffuse large B-cell lymphoma cell lines

Dysregulated expression of BCL-2 family proteins allows cancer cells to escape apoptosis. To counter this, BH3-mimetic drugs that target and inhibit select BCL-2 prosurvival proteins to induce apoptosis have been developed for cancer therapy. Venetoclax, which targets BCL-2, has been effective as th...

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Publicat a:Blood Adv
Autors principals: Diepstraten, Sarah T., Chang, Catherine, Tai, Lin, Gong, Jia-nan, Lan, Ping, Dowell, Alexander C., Taylor, Graham S., Strasser, Andreas, Kelly, Gemma L.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2020
Matèries:
Lymphoid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6988404/
https://ncbi.nlm.nih.gov/pubmed/31985804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000541
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