Integrating pathway elucidation with yeast engineering to produce polpunonic acid the precursor of the anti-obesity agent celastrol

BACKGROUND: Celastrol is a promising anti-obesity agent that acts as a sensitizer of the protein hormone leptin. Despite its potent activity, a sustainable source of celastrol and celastrol derivatives for further pharmacological studies is lacking. RESULTS: To elucidate the celastrol biosynthetic p...

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Detalhes bibliográficos
Publicado no:Microb Cell Fact
Main Authors: Hansen, Nikolaj L., Miettinen, Karel, Zhao, Yong, Ignea, Codruta, Andreadelli, Aggeliki, Raadam, Morten H., Makris, Antonios M., Møller, Birger L., Stærk, Dan, Bak, Søren, Kampranis, Sotirios C.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6988343/
https://ncbi.nlm.nih.gov/pubmed/31992268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-020-1284-9
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