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Mechanisms of Innate Immune Activation by a Hybrid Alphavirus–Rhabdovirus Vaccine Platform

Virus-like vesicles (VLV) are infectious, self-propagating alphavirus-vesiculovirus hybrid vaccine vectors that can be engineered to express foreign antigens to elicit a protective immune response. VLV are highly immunogenic and nonpathogenic in vivo, and we hypothesize that the unique replication a...

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Detalhes bibliográficos
Publicado no:J Interferon Cytokine Res
Main Authors: Marchese, Anthony M., Chiale, Carolina, Moshkani, Safiehkhatoon, Robek, Michael D.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc., publishers 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6987738/
https://ncbi.nlm.nih.gov/pubmed/31633442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/jir.2019.0123
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