Cucurbitacin B and I inhibits colon cancer growth by targeting the Notch signaling pathway

Cancer stem cells (CSCs) have the ability to self-renew and induce drug resistance and recurrence in colorectal cancer (CRC). As current chemotherapy doesn’t eliminate CSCs completely, there is a need to identify novel agents to target them. We investigated the effects of cucurbitacin B (C-B) or I (...

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Publicado en:Sci Rep
Autores principales: Dandawate, Prasad, Subramaniam, Dharmalingam, Panovich, Peyton, Standing, David, Krishnamachary, Balaji, Kaushik, Gaurav, Thomas, Sufi Mary, Dhar, Animesh, Weir, Scott J., Jensen, Roy A., Anant, Shrikant
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6987129/
https://ncbi.nlm.nih.gov/pubmed/31992775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-57940-9
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