TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential

TrkH is a bacterial ion channel implicated in K(+) uptake and pH regulation. TrkH assembles with its regulatory protein, TrkA, which closes the channel when bound to ADP and opens it when bound to ATP. However, it is unknown how nucleotides control the gating of TrkH through TrkA. Here we report the...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nat Commun
Hlavní autoři: Zhang, Hanzhi, Pan, Yaping, Hu, Liya, Hudson, M. Ashley, Hofstetter, Katrina S., Xu, Zhichun, Rong, Mingqiang, Wang, Zhao, Prasad, B. V. Venkataram, Lockless, Steve W., Chiu, Wah, Zhou, Ming
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6987127/
https://ncbi.nlm.nih.gov/pubmed/31992706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14240-9
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky