The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis

BACKGROUND: The molecular chaperone TRAP1, the mitochondrial isoform of cytosolic HSP90, remains poorly understood with respect to its pivotal role in the regulation of mitochondrial metabolism. Most studies have found it to be an inhibitor of mitochondrial oxidative phosphorylation (OXPHOS) and an...

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Detalhes bibliográficos
Publicado no:BMC Biol
Main Authors: Joshi, Abhinav, Dai, Li, Liu, Yanxin, Lee, Jungsoon, Ghahhari, Nastaran Mohammadi, Segala, Gregory, Beebe, Kristin, Jenkins, Lisa M., Lyons, Gaelyn C., Bernasconi, Lilia, Tsai, Francis T. F., Agard, David A., Neckers, Len, Picard, Didier
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6986101/
https://ncbi.nlm.nih.gov/pubmed/31987035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-020-0740-7
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