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Improving phytosterol biotransformation at low nitrogen levels by enhancing the methylcitrate cycle with transcriptional regulators PrpR and GlnR of Mycobacterium neoaurum

BACKGROUND: Androstenedione (AD) is an important steroid medicine intermediate that is obtained via the degradation of phytosterols by mycobacteria. The production process of AD is mainly the degradation of the phytosterol aliphatic side chain, which is accompanied by the production of propionyl CoA...

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Bibliografiske detaljer
Udgivet i:Microb Cell Fact
Main Authors: Zhang, Yang, Zhou, Xiuling, Wang, Xuemei, Wang, Lu, Xia, Menglei, Luo, Jianmei, Shen, Yanbing, Wang, Min
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6986058/
https://ncbi.nlm.nih.gov/pubmed/31992309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-020-1285-8
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