Improving phytosterol biotransformation at low nitrogen levels by enhancing the methylcitrate cycle with transcriptional regulators PrpR and GlnR of Mycobacterium neoaurum

BACKGROUND: Androstenedione (AD) is an important steroid medicine intermediate that is obtained via the degradation of phytosterols by mycobacteria. The production process of AD is mainly the degradation of the phytosterol aliphatic side chain, which is accompanied by the production of propionyl CoA...

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Detalhes bibliográficos
Publicado no:Microb Cell Fact
Main Authors: Zhang, Yang, Zhou, Xiuling, Wang, Xuemei, Wang, Lu, Xia, Menglei, Luo, Jianmei, Shen, Yanbing, Wang, Min
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6986058/
https://ncbi.nlm.nih.gov/pubmed/31992309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-020-1285-8
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