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Choice of library size normalization and statistical methods for differential gene expression analysis in balanced two-group comparisons for RNA-seq studies
BACKGROUND: High-throughput RNA sequencing (RNA-seq) has evolved as an important analytical tool in molecular biology. Although the utility and importance of this technique have grown, uncertainties regarding the proper analysis of RNA-seq data remain. Of primary concern, there is no consensus regar...
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Udgivet i: | BMC Genomics |
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Main Authors: | , , , |
Format: | Artigo |
Sprog: | Inglês |
Udgivet: |
BioMed Central
2020
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Fag: | |
Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6986029/ https://ncbi.nlm.nih.gov/pubmed/31992223 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-020-6502-7 |
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