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Evaluation of statistical methods for normalization and differential expression in mRNA-Seq experiments

BACKGROUND: High-throughput sequencing technologies, such as the Illumina Genome Analyzer, are powerful new tools for investigating a wide range of biological and medical questions. Statistical and computational methods are key for drawing meaningful and accurate conclusions from the massive and com...

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Detalhes bibliográficos
Main Authors: Bullard, James H, Purdom, Elizabeth, Hansen, Kasper D, Dudoit, Sandrine
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838869/
https://ncbi.nlm.nih.gov/pubmed/20167110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-11-94
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