Mitochondrial dysfunction mediated through dynamin-related protein 1 (Drp1) propagates impairment in blood brain barrier in septic encephalopathy

BACKGROUND: Out of the myriad of complications associated with septic shock, septic-associated encephalopathy (SAE) carries a significant risk of morbidity and mortality. Blood-brain-barrier (BBB) impairment, which subsequently leads to increased vascular permeability, has been associated with neuro...

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Pubblicato in:J Neuroinflammation
Autori principali: Haileselassie, Bereketeab, Joshi, Amit U., Minhas, Paras S., Mukherjee, Riddhita, Andreasson, Katrin I., Mochly-Rosen, Daria
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
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Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6986002/
https://ncbi.nlm.nih.gov/pubmed/31987040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-019-1689-8
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