TBAJ-876 Displays Bedaquiline-Like Mycobactericidal Potency without Retaining the Parental Drug’s Uncoupler Activity

The diarylquinoline F(1)F(O)-ATP synthase inhibitor bedaquiline (BDQ) displays protonophore activity. Thus, uncoupling electron transport from ATP synthesis appears to be a second mechanism of action of this antimycobacterial drug. Here, we show that the new BDQ analogue TBAJ-876 did not retain the...

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Bibliografiska uppgifter
I publikationen:Antimicrob Agents Chemother
Huvudupphovsmän: Sarathy, Jickky Palmae, Ragunathan, Priya, Cooper, Christopher B., Upton, Anna M., Grüber, Gerhard, Dick, Thomas
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2020
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Mechanisms of Action: Physiological Effects
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985740/
https://ncbi.nlm.nih.gov/pubmed/31712198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01540-19
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