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Biodistribution and pharmacokinetic profiles of an altered peptide ligand derived from heat-shock proteins 60 in Lewis rats

Human heat-shock protein 60 (HSP60) is an autoantigen involved in the pathogenesis of rheumatoid arthritis (RA). Epitopes derived from HSP60 can trigger activation of regulatory T cells (Treg). CIGB-814 is an altered peptide ligand (APL) derived from HSP60. In preclinical models, this peptide had an...

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Bibliografiske detaljer
Udgivet i:Cell Stress Chaperones
Main Authors: del Carmen Domínguez, María, Cabrales, Ania, Lorenzo, Norailys, Padrón, Gabriel, Gonzalez, L. J.
Format: Artigo
Sprog:Inglês
Udgivet: Springer Netherlands 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985321/
https://ncbi.nlm.nih.gov/pubmed/31802366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12192-019-01054-3
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