APL1, an altered peptide ligand derived from human heat-shock protein 60, increases the frequency of Tregs and its suppressive capacity against antigen responding effector CD4 + T cells from rheumatoid arthritis patients

Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by a chronic relapsing-remitting joint inflammation. Perturbations in the balance between CD4 + T cells producing IL-17 and CD4 + CD25(high)FoxP3 + Tregs correlate with irreversible bone and cartilage destruction in RA. APL1 is...

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Detalhes bibliográficos
Publicado no:Cell Stress Chaperones
Main Authors: Barberá, Ariana, Lorenzo, Noraylis, van Kooten, Peter, van Roon, Joel, de Jager, Wilco, Prada, Dinorah, Gómez, Jorge, Padrón, Gabriel, van Eden, Willem, Broere, Femke, del Carmen Domínguez, María
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Netherlands 2016
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4908004/
https://ncbi.nlm.nih.gov/pubmed/27241313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12192-016-0698-0
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