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High-Salt Loading Downregulates Nrf2 Expression in a Sodium-Dependent Manner in Renal Collecting Duct Cells

BACKGROUND: High salt intake is associated with both oxidative stress and chronic kidney disease (CKD) progression. Nuclear factor E2-related factor 2 (Nrf2) is a transcriptional factor regulating the antioxidant and detoxifying genes to potently antagonize oxidative stress. This study examined the...

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Publicat a:Front Physiol
Autors principals: Liu, Mi, Deng, Mokan, Luo, Qimei, Dou, Xianrui, Jia, Zhanjun
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985211/
https://ncbi.nlm.nih.gov/pubmed/32038274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2019.01565
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