Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes

Zika virus (ZIKV) has been extensively studied since it was linked to congenital malformations, and recent research has revealed that astrocytes are targets of ZIKV. However, the consequences of ZIKV infection, especially to this cell type, remain largely unknown, particularly considering integrativ...

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Publicado no:Sci Rep
Main Authors: Ledur, Pítia Flores, Karmirian, Karina, Pedrosa, Carolina da Silva Gouveia, Souza, Leticia Rocha Quintino, Assis-de-Lemos, Gabriela, Martins, Thiago Martino, Ferreira, Jéssica de Cassia Cavalheiro Gomes, de Azevedo Reis, Gabriel Ferreira, Silva, Eduardo Santos, Silva, Débora, Salerno, José Alexandre, Ornelas, Isis Moraes, Devalle, Sylvie, Madeiro da Costa, Rodrigo Furtado, Goto-Silva, Livia, Higa, Luiza Mendonça, Melo, Adriana, Tanuri, Amilcar, Chimelli, Leila, Murata, Marcos Massao, Garcez, Patrícia Pestana, Filippi-Chiela, Eduardo Cremonese, Galina, Antonio, Borges, Helena Lobo, Rehen, Stevens Kastrup
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985105/
https://ncbi.nlm.nih.gov/pubmed/31988337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-57914-x
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