Brucella abortus Infection Elicited Hepatic Stellate Cell-Mediated Fibrosis Through Inflammasome-Dependent IL-1β Production

In human brucellosis, the liver is frequently affected. Brucella abortus triggers a profibrotic response on hepatic stellate cells (HSCs) characterized by inhibition of MMP-9 with concomitant collagen deposition and TGF-β1 secretion through type 4 secretion system (T4SS). Taking into account that it...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Arriola Benitez, Paula Constanza, Pesce Viglietti, Ayelén Ivana, Gomes, Marco Tulio R., Oliveira, Sergio Costa, Quarleri, Jorge Fabián, Giambartolomei, Guillermo Hernán, Delpino, María Victoria
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985094/
https://ncbi.nlm.nih.gov/pubmed/32038610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.03036
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