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Simultaneous Knockdown of Sprouty2 and PTEN Promotes Axon Elongation of Adult Sensory Neurons

Sprouty2 (Spry2) and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) are both well-established regulators of receptor tyrosine kinase (RTK) signaling, and knockdown of Spry2 or PTEN enhances axon regeneration of dorsal root ganglia (DRG) neurons. The major role of Spry2 is the inhibit...

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Pubblicato in:Front Cell Neurosci
Autori principali: Jamsuwan, Sataporn, Klimaschewski, Lars, Hausott, Barbara
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985068/
https://ncbi.nlm.nih.gov/pubmed/32038175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00583
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