Engineering viable foot-and-mouth disease viruses with increased acid stability facilitate the development of improved vaccines

Foot-and-mouth disease virus (FMDV), the most acid-unstable virus among picornaviruses, tends to disassemble into pentamers at pH values slightly below neutrality. However, the structural integrity of intact virion is one of the most important factors that influence the induction of a protective ant...

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Detalles Bibliográficos
Publicado en:Appl Microbiol Biotechnol
Main Authors: Yuan, Hong, Li, Pinghua, Bao, Huifang, Sun, Pu, Bai, Xingwen, Bai, Qifeng, Li, Na, Ma, Xueqing, Cao, Yimei, Fu, Yuanfang, Li, Kun, Zhang, Jing, Li, Dong, Chen, Yingli, Zhang, Jie, Lu, Zengjun, Liu, Zaixin
Formato: Artigo
Idioma:Inglês
Publicado: Springer Berlin Heidelberg 2020
Assuntos:
Applied Genetics and Molecular Biotechnology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985056/
https://ncbi.nlm.nih.gov/pubmed/31900553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00253-019-10280-9
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