Engineering viable foot-and-mouth disease viruses with increased acid stability facilitate the development of improved vaccines

Foot-and-mouth disease virus (FMDV), the most acid-unstable virus among picornaviruses, tends to disassemble into pentamers at pH values slightly below neutrality. However, the structural integrity of intact virion is one of the most important factors that influence the induction of a protective ant...

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Vydáno v:Appl Microbiol Biotechnol
Hlavní autoři: Yuan, Hong, Li, Pinghua, Bao, Huifang, Sun, Pu, Bai, Xingwen, Bai, Qifeng, Li, Na, Ma, Xueqing, Cao, Yimei, Fu, Yuanfang, Li, Kun, Zhang, Jing, Li, Dong, Chen, Yingli, Zhang, Jie, Lu, Zengjun, Liu, Zaixin
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2020
Témata:
Applied Genetics and Molecular Biotechnology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985056/
https://ncbi.nlm.nih.gov/pubmed/31900553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00253-019-10280-9
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