STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells

Alterations involving serine-threonine phosphatase PP2A subunits occur in a range of human cancers, and partial loss of PP2A function contributes to cell transformation. Displacement of regulatory B subunits by the SV40 Small T antigen (ST) or mutation/deletion of PP2A subunits alters the abundance...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Kim, Jong Wook, Berrios, Christian, Kim, Miju, Schade, Amy E, Adelmant, Guillaume, Yeerna, Huwate, Damato, Emily, Iniguez, Amanda Balboni, Florens, Laurence, Washburn, Michael P, Stegmaier, Kim, Gray, Nathanael S, Tamayo, Pablo, Gjoerup, Ole, Marto, Jarrod A, DeCaprio, James, Hahn, William C
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6984821/
https://ncbi.nlm.nih.gov/pubmed/31913126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.53003
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