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Neuronal autophagy declines substantially with age and is rescued by overexpression of WIPI2

Macroautophagy/autophagy is implicated in age-dependent neurodegenerative diseases, including amyotrophic lateral sclerosis and Parkinson, Huntington and Alzheimer diseases, suggesting that an age-related decline in neuronal autophagy may contribute to the onset of neurodegeneration. We identified a...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Stavoe, Andrea K. H., Holzbaur, Erika L. F.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6984449/
https://ncbi.nlm.nih.gov/pubmed/31794336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1695401
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