Synthesis and evaluation of (13)C-labeled 5-5-dimethyl-1-pyrroline-N-oxide aimed at in vivo detection of reactive oxygen species using hyperpolarized (13)C-MRI

Effective means to identify the role of reactive oxygen species (ROS) mediating several diseases including cancer, ischemic heart disease, stroke, Alzheimer’s and other inflammatory conditions in in vivo models would be useful. The cyclic nitrone 5,5-Dimethyl-1-pyrroline-N-oxide (DMPO) is a spin tra...

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Detalhes bibliográficos
Publicado no:Free Radic Biol Med
Main Authors: Saito, Keita, Sail, Deepak, Yamamoto, Kazutoshi, Matsumoto, Shingo, Blackman, Burchelle, Kishimoto, Shun, Brender, Jeffery, Swenson, Rolf E., Mitchell, James B., Krishna, Murali C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983923/
https://ncbi.nlm.nih.gov/pubmed/30471347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2018.11.013
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