Synthesis and evaluation of (13)C-labeled 5-5-dimethyl-1-pyrroline-N-oxide aimed at in vivo detection of reactive oxygen species using hyperpolarized (13)C-MRI

Effective means to identify the role of reactive oxygen species (ROS) mediating several diseases including cancer, ischemic heart disease, stroke, Alzheimer’s and other inflammatory conditions in in vivo models would be useful. The cyclic nitrone 5,5-Dimethyl-1-pyrroline-N-oxide (DMPO) is a spin tra...

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Vydáno v:Free Radic Biol Med
Hlavní autoři: Saito, Keita, Sail, Deepak, Yamamoto, Kazutoshi, Matsumoto, Shingo, Blackman, Burchelle, Kishimoto, Shun, Brender, Jeffery, Swenson, Rolf E., Mitchell, James B., Krishna, Murali C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983923/
https://ncbi.nlm.nih.gov/pubmed/30471347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2018.11.013
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