Synthesis and evaluation of (13)C-labeled 5-5-dimethyl-1-pyrroline-N-oxide aimed at in vivo detection of reactive oxygen species using hyperpolarized (13)C-MRI

Effective means to identify the role of reactive oxygen species (ROS) mediating several diseases including cancer, ischemic heart disease, stroke, Alzheimer’s and other inflammatory conditions in in vivo models would be useful. The cyclic nitrone 5,5-Dimethyl-1-pyrroline-N-oxide (DMPO) is a spin tra...

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Bibliografske podrobnosti
izdano v:Free Radic Biol Med
Main Authors: Saito, Keita, Sail, Deepak, Yamamoto, Kazutoshi, Matsumoto, Shingo, Blackman, Burchelle, Kishimoto, Shun, Brender, Jeffery, Swenson, Rolf E., Mitchell, James B., Krishna, Murali C.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983923/
https://ncbi.nlm.nih.gov/pubmed/30471347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2018.11.013
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