Src Kinase Is Biphosphorylated at Y416/Y527 and Activates the CUB-Domain Containing Protein 1/Protein Kinase C δ Pathway in a Subset of Triple-Negative Breast Cancers

Targeted therapeutics are needed for triple-negative breast cancer (TNBC). In this study, we investigated the activation of Src family of cytoplasmic tyrosine kinases (SFKs) and two SFK substrates—CUB-domain containing protein 1 (CDCP1) and protein kinase C δ (PKCδ)—in 56 formalin-fixed, paraffin-em...

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Publicado en:Am J Pathol
Main Authors: Nelson, Luke J., Wright, Heather J., Dinh, Nguyen B., Nguyen, Kevin D., Razorenova, Olga V., Heinemann, F. Scott
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983918/
https://ncbi.nlm.nih.gov/pubmed/31843498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2019.10.017
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