Disruption of hepatic small heterodimer partner induces dissociation of steatosis and inflammation in experimental nonalcoholic steatohepatitis

Nonalcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease worldwide and is characterized by steatosis, inflammation, and fibrosis. The molecular mechanisms underlying NASH development remain obscure. The nuclear receptor small heterodimer partner (Shp) plays a complex role in l...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Magee, Nancy, Zou, An, Ghosh, Priyanka, Ahamed, Forkan, Delker, Don, Zhang, Yuxia
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2020
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983844/
https://ncbi.nlm.nih.gov/pubmed/31831621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010233
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