Overexpression of mitochondrial histidyl-tRNA synthetase restores mitochondrial dysfunction caused by a deafness-associated tRNA(His) mutation

The deafness-associated m.12201T>C mutation affects the A5-U68 base-pairing within the acceptor stem of mitochondrial tRNA(His). The primary defect in this mutation is an alteration in tRNA(His) aminoacylation. Here, we further investigate the molecular mechanism of the deafness-associated tRNA(H...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Gong, Shasha, Wang, Xiaoqiong, Meng, Feilong, Cui, Limei, Yi, Qiuzi, Zhao, Qiong, Cang, Xiaohui, Cai, Zhiyi, Mo, Jun Qin, Liang, Yong, Guan, Min-Xin
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2020
Matèries:
RNA
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983842/
https://ncbi.nlm.nih.gov/pubmed/31819004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010998
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