Class III PI3K Vps34 Controls Thyroid Hormone Production by Regulating Thyroglobulin Iodination, Lysosomal Proteolysis, and Tissue Homeostasis

Background: The production of thyroid hormones [triiodothyronine (T3), thyroxine (T4)] depends on the organization of the thyroid in follicles, which are lined by a monolayer of thyrocytes with strict apicobasal polarity. This polarization supports vectorial transport of thyroglobulin (Tg) for stora...

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Udgivet i:Thyroid
Main Authors: Grieco, Giuseppina, Wang, Tongsong, Delcorte, Ophélie, Spourquet, Catherine, Janssens, Virginie, Strickaert, Aurélie, Gaide Chevronnay, Héloïse P., Liao, Xiao-Hui, Bilanges, Benoît, Refetoff, Samuel, Vanhaesebroeck, Bart, Maenhaut, Carine, Courtoy, Pierre J., Pierreux, Christophe E.
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc., publishers 2020
Fag:
Thyroid Economy: Regulation, Cell Biology, and Thyroid Hormone Metabolism and Action
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983755/
https://ncbi.nlm.nih.gov/pubmed/31650902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/thy.2019.0182
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