A Mouse Model Suggests Two Mechanisms for Thyroid Alterations in Infantile Cystinosis: Decreased Thyroglobulin Synthesis Due to Endoplasmic Reticulum Stress/Unfolded Protein Response and Impaired Lysosomal Processing

Thyroid hormones are released from thyroglobulin (Tg) in lysosomes, which are impaired in infantile/nephropathic cystinosis. Cystinosis is a lysosomal cystine storage disease due to defective cystine exporter, cystinosin. Cystinotic children develop subclinical and then overt hypothyroidism. Why hyp...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Endocrinology
Main Authors: Gaide Chevronnay, H. P., Janssens, V., Van Der Smissen, P., Liao, X. H., Abid, Y., Nevo, N., Antignac, C., Refetoff, S., Cherqui, S., Pierreux, C. E., Courtoy, P. J.
Format: Artigo
Jezik:Inglês
Izdano: Endocrine Society 2015
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4430621/
https://ncbi.nlm.nih.gov/pubmed/25811319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1672
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki