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Tissue transglutaminase 2 regulates tumor cell tensional homeostasis by increasing contractility

Abnormal tensional cellular homeostasis is now considered a hallmark of cancer. Despite this, the origin of this abnormality remains unclear. In this work, we investigated the role of tissue transglutaminase 2 (TG2, also known as TGM2), a protein associated with poor prognosis and increased metastat...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Cell Sci
Hauptverfasser: Bordeleau, Francois, Wang, Wenjun, Simmons, Alysha, Antonyak, Marc A., Cerione, Richard A., Reinhart-King, Cynthia A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists Ltd 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983728/
https://ncbi.nlm.nih.gov/pubmed/31822629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.231134
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