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Identification and Biological Evaluation of CK2 Allosteric Fragments through Structure-Based Virtual Screening
Casein kinase II (CK2) is considered as an attractive cancer therapeutic target, and recent efforts have been made to develop its ATP-competitive inhibitors. However, achieving selectivity with respect to related kinases remains challenging due to the highly conserved ATP-binding pocket of kinases....
Kaydedildi:
| Yayımlandı: | Molecules |
|---|---|
| Asıl Yazarlar: | , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
MDPI
2020
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6983002/ https://ncbi.nlm.nih.gov/pubmed/31935979 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25010237 |
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