Identification and Biological Evaluation of CK2 Allosteric Fragments through Structure-Based Virtual Screening

Casein kinase II (CK2) is considered as an attractive cancer therapeutic target, and recent efforts have been made to develop its ATP-competitive inhibitors. However, achieving selectivity with respect to related kinases remains challenging due to the highly conserved ATP-binding pocket of kinases....

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Veröffentlicht in:Molecules
Hauptverfasser: Li, Chunqiong, Zhang, Xuewen, Zhang, Na, Zhou, Yue, Sun, Guohui, Zhao, Lijiao, Zhong, Rugang
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983002/
https://ncbi.nlm.nih.gov/pubmed/31935979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25010237
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