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In Silico Design and Molecular Basis for the Selectivity of Olinone Towards the First over the Second Bromodomain of BRD4
Bromodomains (BrDs), a conserved structural module in chromatin-associated proteins, are well known for recognizing ε-N-acetyl lysine residues on histones. One of the most relevant BrDs is BRD4, a tandem bromodomain containing protein (BrD1 and BrD2) that plays a critical role in numerous diseases i...
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| Udgivet i: | Proteins |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6982606/ https://ncbi.nlm.nih.gov/pubmed/31587361 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.25818 |
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