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Exploiting RAS Nucleotide Cycling as a Strategy for Drugging RAS-Driven Cancers

Oncogenic mutations in RAS genes result in the elevation of cellular active RAS protein levels and increased signal propagation through downstream pathways that drive tumor cell proliferation and survival. These gain-of-function mutations drive over 30% of all human cancers, presenting promising the...

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Bibliografiske detaljer
Udgivet i:Int J Mol Sci
Main Authors: Mattox, Tyler E., Chen, Xi, Maxuitenko, Yulia Y., Keeton, Adam B., Piazza, Gary A.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6982188/
https://ncbi.nlm.nih.gov/pubmed/31878223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21010141
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