Cardiac-Specific Overexpression of Catalytically Inactive Corin Reduces Edema, Contractile Dysfunction, and Death in Mice with Dilated Cardiomyopathy

Humans with dilated cardiomyopathy (DCM) and heart failure (HF) develop low levels of corin, a multi-domain, cardiac-selective serine protease involved in natriuretic peptide cleavage and sodium and water regulation. However, experimental restoration of corin levels markedly attenuates HF progressio...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Tripathi, Ranjana, Sullivan, Ryan D., Fan, Tai-Hwang M., Houng, Aiilyan K., Mehta, Radhika M., Reed, Guy L., Gladysheva, Inna P.
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6981738/
https://ncbi.nlm.nih.gov/pubmed/31892216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21010203
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